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. 1983;232(3):565-77.
doi: 10.1007/BF00216429.

Regeneration of mammalian skeletal muscle following the injection of the snake-venom toxin, taipoxin

C A Maltin, J B Harris, M J Cullen

Regeneration of mammalian skeletal muscle following the injection of the snake-venom toxin, taipoxin

C A Maltin et al. Cell Tissue Res. 1983.

Abstract

Taipoxin, a toxin isolated from the venom of the snake Oxyuranus scutellatus was injected subcutaneously into the anterolateral aspect of one hind limb of the rat. The toxin caused a necrotising myopathy in the underlying muscle. The ultrastructural characteristics of the regeneration that followed the administration of the myotoxin were studied. Regeneration occurred within the surviving basal lamina tubes from a population of spared satellite cells. Myotubes were formed by 3 days and small immature muscle fibres by 5 days. The regenerative response was total and very rapid. Highly activated satellite cells were found in apparently undamaged fibres in the toxin-damaged muscles. Many of these cells appeared to be motile, having cytoplasmic processes which seemed to be passing through the basal lamina of the parent muscle fibres.

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