The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells
- PMID: 6884518
- DOI: 10.1016/0014-5793(83)80944-2
The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells
Abstract
Exposure of 'leaky' bovine adrenal medullary cells to the phorbol ester TPA causes a shift in the calcium-activation curve to lower calcium concentrations without altering the levels of secretion at the extremes of the activation curve. These results are consistent with a role for protein kinase C in exocytosis.
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