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. 1983 Sep 5;161(1):140-4.
doi: 10.1016/0014-5793(83)80747-9.

Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites

C Goffin, W G Verly
Free article

Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites

C Goffin et al. FEBS Lett. .
Free article

Abstract

Storage of a solution of DNA containing apurinic sites, even at 4 degrees C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.

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