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. 1983 Jul;104(3):449-56.
doi: 10.1093/genetics/104.3.449.

Evidence for balancing selection at HLA

P W Hedrick, G Thomson

Evidence for balancing selection at HLA

P W Hedrick et al. Genetics. 1983 Jul.

Abstract

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

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References

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