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Comparative Study
. 1983 Sep;41(3):1383-5.
doi: 10.1128/iai.41.3.1383-1385.1983.

Induction of oral tolerance in mice unresponsive to bacterial lipopolysaccharide

M G Saklayen, A J Pesce, V E Pollak, J G Michael
Comparative Study

Induction of oral tolerance in mice unresponsive to bacterial lipopolysaccharide

M G Saklayen et al. Infect Immun. 1983 Sep.

Abstract

C3H/HeJ lipopolysaccharide (LPS)-unresponsive and closely related C3H/HeSn LPS-responsive mice were rendered tolerant to hen albumin by antigen feeding before parenteral immunization. Both single and multiple feedings of antigen were effective in inducing tolerance to hen albumin in LPS-responsive and -unresponsive strains of mice. Our data demonstrate that ability to respond to LPS is not a prerequisite for induction of oral tolerance to a soluble protein antigen.

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