doi: 10.3109/03008207709152609.
Collagenase and its natural inhibitors in relation to the rheumatoid joint
- PMID: 68852
- DOI: 10.3109/03008207709152609
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Collagenase and its natural inhibitors in relation to the rheumatoid joint
Connect Tissue Res.
1977.
Abstract
This report attempts to summarize our present knowledge of rheumatoid synovial collagenase and its natural serum inhibitors, beta1-anticollagenase and alpha2-macroglobulin, in relation to cartilage collagen resorption in the rheumatoid joint. Immunolocalization of collagenase across the cartilage/pannus junction is described, and in the light of the finding of the specific, small molecular weight beta1-anticollagenase we propose a model of cartilage erosion based on the interaction between collagenase and its natural inhibitors.
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