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. 1978 Sep;24(3):294-7.
doi: 10.1002/cpt1978243294.

Effects of folic acid on phenytoin kinetics in healthy subjects

M Furlanut, P Benetello, A Avogaro, R Dainese

Effects of folic acid on phenytoin kinetics in healthy subjects

M Furlanut et al. Clin Pharmacol Ther. 1978 Sep.

Abstract

Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.

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