doi: 10.1002/cpt1978243294.
Effects of folic acid on phenytoin kinetics in healthy subjects
- PMID: 688723
- DOI: 10.1002/cpt1978243294
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Effects of folic acid on phenytoin kinetics in healthy subjects
Clin Pharmacol Ther.
1978 Sep.
Abstract
Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.
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