Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Oct;24(4):474-8.
doi: 10.1002/cpt1978244474.

Alterations in state in apneic pre-term infants receiving theophylline

J Dietrich, A N Krauss, M Reidenberg, D E Drayer, P A Auld

Alterations in state in apneic pre-term infants receiving theophylline

J Dietrich et al. Clin Pharmacol Ther. 1978 Oct.

Abstract

The present study is a report on 9 premature infants treated with aminophylline for relief of apnea. With serum theophylline levels of 2 to 10 microgram/ml, all infants experienced significant decrease of apneic episodes in association with increased wakefulness and increased amounts of active (REM) sleep. These effects may occur independently, but it is possible that the alteration of sleep states may be partially responsible for the decrease in apneic episodes in these infants.

PubMed Disclaimer

MeSH terms