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. 1983 May;8(5):687-99.
doi: 10.1007/BF00964706.

A central mechanism of action for taurine: osmoregulation, bivalent cations, and excitation threshold

N M van Gelder

A central mechanism of action for taurine: osmoregulation, bivalent cations, and excitation threshold

N M van Gelder. Neurochem Res. 1983 May.

Abstract

A postulated zinc-taurine complex, with a zinc affinity intermediate between that for glutamic acid dehydrogenase and the calcium binding protein(s), provides an explanation for a series of seemingly unrelated biochemical and physiological effects of taurine. The proposed complex suggests a central mechanism for the action of taurine, such as a bicarbonate and pH dependent influence on calcium and zinc movements (and vice versa), the osmoregulatory role of taurine, and its effect on the excitation threshold.

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