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Comparative Study
. 1982 Dec 15;38(12):1469-70.
doi: 10.1007/BF01955775.

Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL mice

K Blum, A H Briggs, L DeLallo, S F Elston, R Ochoa
Comparative Study

Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL mice

K Blum et al. Experientia. .

Abstract

These experiments systematically investigated ethanol preference in both the C57Bl/6N and C57Bl/6J mice utilizing three-choice 2-bottle preference test. In addition, these sublines were evaluated for whole brain methionine-enkephalin levels, which were significantly lower in C57Bl/6J mice (alcohol preferring) compared to C57Bl/6N mice (alcohol non-preferring). This finding supports the involvement of the peptidyl opiates in ethanol seeking behavior.

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