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. 1980 Mar;50(3):480-4.
doi: 10.1210/jcem-50-3-480.

Stimulation of 1,25-dihydroxyvitamin D production by parathyroid hormone and hypocalcemia in man

B Lund, O H Sørensen, B Lund, J E Bishop, A W Norman

Stimulation of 1,25-dihydroxyvitamin D production by parathyroid hormone and hypocalcemia in man

B Lund et al. J Clin Endocrinol Metab. 1980 Mar.

Abstract

The serum levels of 1.25-dihydroxycholecalciferol [1,25(OH)2D3] were increased in five patients with primary hyperparathyroidism [60 +/- 13 (SD) pg/ml; normal value, 33 +/- 15 (SD) pg/ml] but fell rapidly after parathyroidectomy to values of 23 +/- 9 (SD) pg/ml. This was accompanied by parallel decreases in the serum concentrations of calcium and immunoreactive parathyroid hormone. Over the following 5--35 days, the serum 1,25(OH)2D3 concentrations increased markedly to levels of 59 +/- 17 (SD) pg/ml, which could most likely be explained by a stimulatory effect of the hypocalcemia per se on the renal production of 1,25(OH)2D3.

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