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Case Reports
. 1980 Nov;55(11):894-5.
doi: 10.1136/adc.55.11.894.

Thyroid-stimulating immunoglobulins in neonatal Graves's disease

C S Teng, T C Tong, J H Hutchison, R T Yeung
Case Reports

Thyroid-stimulating immunoglobulins in neonatal Graves's disease

C S Teng et al. Arch Dis Child. 1980 Nov.

Abstract

Two patients with neonatal Graves's disease are reported. One of them had a delayed onset because of suppression of the fetal thyroid gland by antithyroid drug taken by the mother during pregnancy. Thyroid-stimulating immunoglobulins (TSAb), measured by a receptor assay, were present in both babies when they were thyrotoxic, and also in their mothers. TSAb were undetectable in both babies 1 year after birth. This strongly supports a pathogenetic role of TSAb in this condition through transplacental transfer of maternal TSAb.

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