Actin-containing matrix associated with the plasma membrane of murine tumour and lymphoid cells

Abstract

A detergent-insoluble matrix has been isolated from murine tumour cell and lymphocyte plasma membranes. The major components of this matrix include actin and four additional proteins not previously identified as cytoskeletal proteins. Labelling studies indicate that the matrix is located on the inner face of the plasma membrane. A cell-surface glycoprotein, 5'-nucleotidase, remains associated with the isolated matrix.