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. 1980 Oct 17;67(2-3):313-6.
doi: 10.1016/0014-2999(80)90515-4.

Intrathecal morphine in mice: a new technique

J L Hylden, G L Wilcox

Intrathecal morphine in mice: a new technique

J L Hylden et al. Eur J Pharmacol. .

Abstract

A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

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