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Comparative Study
. 1981 Jul;105(7):353-7.

Thrombogenicity of components of atheromatous material. An animal and in vitro model of cerebral atheroembolism

B J Jeynes, B A Warren
  • PMID: 6894688
Comparative Study

Thrombogenicity of components of atheromatous material. An animal and in vitro model of cerebral atheroembolism

B J Jeynes et al. Arch Pathol Lab Med. 1981 Jul.

Abstract

Human atheromatous material was separated into lipid and nonlipid fractions by ether and chloroform-methyl alcohol procedures. The maximum nonlethal doses of nonlipid, lipid, and whole (unseparated) atheromatous material were 8 mg, between 15 and 30 mg, and between 50 and 60 mg when injected into the left common carotid arteries of rabbits. In vitro production of thrombi showed that the nonlipid material produced thrombi that were larger in volume, weight, and length than those produced by whole material.

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