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. 1981 Oct;74(2):322-4.
doi: 10.1111/j.1476-5381.1981.tb09974.x.

The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels

R Carnuccio, M Di Rosa, R J Flower, A Pinto

The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels

R Carnuccio et al. Br J Pharmacol. 1981 Oct.

Abstract

Hydrocortisone inhibits prostaglandin generation by rat peritoneal leucocytes by releasing the polypeptide phospholipase inhibitor, macrocortin. The susceptibility of these cells to hydrocortisone is directly correlated with their intracellular macrocortin content. Cells depleted of the peptide by prior incubation with steroid cannot respond to the steroid, until a fresh intracellular store has been synthesized. In vitro, this process requires 4-5 h. Cells remain sensitive to the inhibitory action of the peptide at all times.

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References

    1. Nat New Biol. 1971 Jun 23;231(25):232-5 - PubMed
    1. Prostaglandins. 1975 Aug;10(2):343-55 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 May;73(5):1730-4 - PubMed
    1. Nature. 1976 Oct 7;263(5577):479-82 - PubMed
    1. Br J Pharmacol. 1976 Jul;57(3):466P-467P - PubMed

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