Effects of molsidomine on coronary artery thrombosis and myocardial ischemia in acute canine experiments

Abstract

Antithrombotic and hemodynamic properties of molsidomine (0.10 mg/kg i.v.) were evaluated in an in-vivo model of coronary artery thrombosis initiated by electrical stimulation for 6 h. Molsidomine prolonged time to vessel occlusion and prevented heart rate and end-diastolic pressure increase and contractility decrease. Infarct size was smaller after drug treatment related either to left ventricle (P less than 0.02) or to vessel area-at-risk (P less than 0.01). It is suggested that molsidomine has antithrombotic effects which might prevent acute coronary infarction.