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Comparative Study
. 1981 Oct 15;75(1):61-4.
doi: 10.1016/0014-2999(81)90346-0.

8-phenyltheophylline: a potent P1-purinoceptor antagonist

S G Griffith, P Meghji, C J Moody, G Burnstock
Comparative Study

8-phenyltheophylline: a potent P1-purinoceptor antagonist

S G Griffith et al. Eur J Pharmacol. .

Abstract

8-Phenyltheophylline was more potent than theophylline in antagonizing the inhibitory effects of adenosine in guinea-pig driven left atrium, rabbit basilar artery and electrically stimulated guinea-pig ileum preparations. In guinea-pig atrium and ileum, the antagonism of adenosine responses by the methylxanthines is of a competitive nature, but in rabbit basilar artery it does not appear to be so. In all three preparations, the effects of theophylline and 8-phenyltheophylline could be reversed by washing. It is concluded that 8-phenyltheophylline is a more potent P1-purinoceptor antagonist than theophylline.

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