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Comparative Study
. 1981 Dec;6(12):539-43.
doi: 10.1007/BF00252666.

Comparative quantitative evaluation of hepatic clearance of diethyl-IDA and para-butyl-IDA in jaundiced and non-jaundiced patients

G L Tarolo, R Picozzi, B Palagi, F Cammelli
Comparative Study

Comparative quantitative evaluation of hepatic clearance of diethyl-IDA and para-butyl-IDA in jaundiced and non-jaundiced patients

G L Tarolo et al. Eur J Nucl Med. 1981 Dec.

Abstract

A method for comparative measurement of hepatic clearance of different hepatobiliary agents is described and the clinical use of diethyl-IDA and parabutyl-IDA is discussed. The study was performed with both radiopharmaceuticals in 13 patients with hepatobiliary disease with serum bilirubin ranging from 0.3 to 16.4 mg/100 ml. Diethyl-IDA is preferable for a qualitative evaluation of hepatobiliary disease because of its higher hepatic clearance and faster biliary excretion rate. Parabutyl-IDA is superior for measuring the hepatocytic uptake function, due to the low urinary excretion and the absence of an apparent re-entry from liver to plasma, even in patients with obstructive jaundice. In contrast, an appreciable re-entry can be demonstrated for diethyl-IDA.

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References

    1. J Nucl Med. 1979 Feb;20(2):171-2 - PubMed
    1. Radiology. 1978 Feb;126(2):467-74 - PubMed
    1. J Nucl Med. 1978 May;19(5):452-7 - PubMed
    1. Eur J Nucl Med. 1979 Oct;4(5):365-8 - PubMed
    1. Eur J Nucl Med. 1980 Aug;5(4):311-2 - PubMed

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