Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug 1;146(2):435-44.
doi: 10.1084/jem.146.2.435.

Evolution of an idiotypic determinant: anti-Val

R A Karol, M Reichlin, R W Noble

Evolution of an idiotypic determinant: anti-Val

R A Karol et al. J Exp Med. .

Abstract

An antibody population which reacts only with human sickle cell hemoglobin (HbS) and not with normal human hemoglobin, has been isolated from goat, sheep, and guinea pig antisera. These antibody populations termed anti-Val (Val), isolated from an individual goat (no. 6) and sheep (no. 26) have been used to elicit anti-idiotypic responses in rabbits. These anti-idiotypic sera were used to study the idiotypic cross-reactions between the goat and sheep anti-Val. Strong cross-reactions were present using either Ra anti-goat anti-Val or Ra anti-sheep anti-Val. Guinea pig anti-Val did not cross-react with these anti-idiotypic sera. Binding of HbS to the anti-Val of the goat and sheep could be blocked by the anti-idiotypic sera, but the binding of HbS to the guinea pig anti-Val could not. These data demonstrate idiotypic cross-reactivity between two closely related species.

PubMed Disclaimer

References

    1. Nature. 1962 May 5;194:495-6 - PubMed
    1. J Exp Med. 1970 Nov;132(5):951-62 - PubMed
    1. J Exp Med. 1970 Oct 1;132(4):737-51 - PubMed
    1. J Exp Med. 1971 Aug 1;134(2):532-52 - PubMed
    1. J Exp Med. 1972 Mar 1;135(3):579-95 - PubMed

Publication types