Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug 1;146(2):606-10.
doi: 10.1084/jem.146.2.606.

Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells

R D Gordon, L E Samelson, E Simpson

Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells

R D Gordon et al. J Exp Med. .

Abstract

T-cell mediated cytotoxic responses to H-Y antigen require co-recognition of H-Y and H-2 gene products. F1 mael stimulating cells and target cells express H-Y antigen in association with both parental H-2 haplotypes. However, F1 females primed in vivo and challenged in vitro with F1 male cells lyse male target cells of F1 and only one parental H-2 haplotype. Thus, (CBA X B10)F1 females sensitized to (CBA X B10)F1 male cells lyse (CBA X B10)F1 and CBA but not B10 male target cells, and (BALB/c X B10)F1 females sensitized to (BALB/c X B10)F1 male cells will lyse (BALB/c X B10)F1 and B10 but not BALB/c male target cells. It is suggested that this may represent an effect of immune response or suppressor genes mapping in the major histocompatibility gene complex which regulate responsiveness to H-Y antigen.

PubMed Disclaimer

References

    1. Nature. 1975 Jul 31;256(5516):419-21 - PubMed
    1. J Exp Med. 1975 Nov 1;142(5):1108-20 - PubMed
    1. J Exp Med. 1976 Mar 1;143(3):601-14 - PubMed
    1. Eur J Immunol. 1976 Jul;5(7):451-5 - PubMed
    1. Transplant Proc. 1977 Mar;9(1):885-8 - PubMed

Publication types