Organization of corticocortical connections in the parietal cortex of the rat

Abstract

An analysis based on Nissl, anterograde degeneration, and succinic dehydrogenase histochemical techniques reveals that there are two distinct regions of parietal cortex which are characterized by different cytoarchitectonic features and anatomical connections. The "granular" cortical zone possesses a well-defined fourth layer composed of small, densely-packed cells, receives dense projections from the ventral posterior nucleus of the thalamus, and is essentially free of callosal inputs. "Agranular" cortical areas which surround or lie embedded within the granular zone lack a well-defined fourth layer, receive sparse projection from the ventral posterior nucleus, but send and receive extensive callosal projections. These findings suggest that thalamic and callosal projections to the parietal cortex maintain a pattern of areal segregation. The granular cortical zone, which apparently corresponds to SmI, projects ipsilaterally to motor cortex, SmII, and adjacent agranular areas. The superficial layers of the granular cortex also project heavily upon the underlying layer V. This intracortical projection is not organized in discrete clusters within the "barrel field" cortex. This suggests that the specialized organization of thalamic afferents and granule cells within the "barrel field" is not maintained in the intracortical circuitry of this region.