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. 1977 Jul;59(1):95-8.
doi: 10.1093/jnci/59.1.95.

Relationship between leukemia antigens and stimulation in mixed leukocyte culture

G Opelz, R P Gale, J D McClelland

Relationship between leukemia antigens and stimulation in mixed leukocyte culture

G Opelz et al. J Natl Cancer Inst. 1977 Jul.

Abstract

Leukemia cells from 13 of 27 patients stimulated lymphocytes of their HLA-identical siblings in mixed leukocyte cultures (MLC). Stimulation correlated with high background uptake of tritiated thymidine and high percentages of cells that stained with fluorescein-conjugated polyvalent goat antiserum against human immunoglobulin. Results were similar to those reported with fractionated autologous lymphocyte subpopulations in normal individuals. Investigation of leukemia-specific stimulation in MLC is therefore problematic.

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