Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Nov 25;8(22):5213-22.
doi: 10.1093/nar/8.22.5213.

A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem

M H de Bruijn, P H Schreier, I C Eperon, B G Barrell, E Y Chen, P W Armstrong, J F Wong, B A Roe
Free PMC article

A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem

M H de Bruijn et al. Nucleic Acids Res. .
Free PMC article

Abstract

A unique transfer RNA has been identified in human and bovine mitochondria that lacks the "dihydrouridine" loop and stem structure. This tRNA is mitochondrially coded as shown by DNA sequence analysis of the human and bovine mitochondrial DNA. Sequence analysis of the RNA shows that it is post-transcriptionally modified by the addition of CCA at the 3' terminus and that at least one base is modified. As predicted by its anticodon (GCU, corresponding to the serine codons AGU/C) this tRNA can be aminoacylated with serine when purified mitochondria are incubated in a medium containing 3H-serine.

PubMed Disclaimer

References

    1. J Mol Biol. 1972 Nov 14;71(2):163-75 - PubMed
    1. J Mol Biol. 1973 Sep 15;79(2):391-410 - PubMed
    1. Biochem Biophys Res Commun. 1974 Jan 23;56(2):401-6 - PubMed
    1. Science. 1974 Aug 2;185(4149):435-40 - PubMed
    1. Biochem Biophys Res Commun. 1974 Oct 23;60(4):1440-5 - PubMed

Publication types

Associated data