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. 1982 Jan 18;700(2):178-83.
doi: 10.1016/0167-4838(82)90095-4.

Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor

F Gauthier, U Fryksmark, K Ohlsson, J G Bieth

Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor

F Gauthier et al. Biochim Biophys Acta. .

Abstract

The rate constant for the association between human leukocyte elastase (EC 3.4.21.11) and human bronchial inhibitor has been determined by competition experiments with alpha 1-proteinase inhibitor. This constant (1.1.10(7) M(-1) . s(-1)) is 6-times lower than that for the association of leukocyte elastase and alpha 1-proteinase inhibitor. The latter inhibitor is able to dissociate the leukocyte elastase-bronchial inhibitor complex with a rate constant 1.3.10(-4) s-1. The equilibrium dissociation constant Ki of the complex is 1.2.10(-11) M. The physiopathological significance of these constants is discussed.

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