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. 1980 May;77(5):2904-8.
doi: 10.1073/pnas.77.5.2904.

Evidence for a naturally occurring anti-spermine antibody in normal rabbit serum

K Furuichi, H Ezoe, T Obara, T Oka

Evidence for a naturally occurring anti-spermine antibody in normal rabbit serum

K Furuichi et al. Proc Natl Acad Sci U S A. 1980 May.

Abstract

Normal rabbit serum contains an IgG-like component(s) that binds spermine as well as other polyamines. This molecule(s) has the same physicochemical properties as anti-spermine antibody obtained from rabbits immunized with spermine-thyroglobulin conjugates. However, the polyamines-binding IgG-like molecule(s), unlike anti-spermine antibody, is incapable either of precipitating a spermine-bovine serum albumin complex or of binding to a spermine-Sepharose column. These results suggest the existence of a naturally occurring anti-polyamine antibody that may have defective antibody functions.

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