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. 1980 May;21(5):397-401.
doi: 10.1136/gut.21.5.397.

Genetic studies in human and murine giardiasis

I C Roberts-Thomson, G F Mitchell, R F Anders, B D Tait, P Kerlin, A Kerr-Grant, P Cavanagh

Genetic studies in human and murine giardiasis

I C Roberts-Thomson et al. Gut. 1980 May.

Abstract

Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.

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