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. 1980:4:322-4.
doi: 10.1007/978-3-642-67729-8_66.

Acrylonitrile metabolism in the rat

J Kopecký, I Gut, J Nerudová, D Zachardová, V Holeĉek, J Filip

Acrylonitrile metabolism in the rat

J Kopecký et al. Arch Toxicol Suppl. 1980.

Abstract

Acrylonitrile (AN) is metabolized by an oxidative pathway via glycidonitrile and glycolaldehyde cyanohydrin to cyanide (CN-), which is transformed to thiocyanate. The major route of AN metabolism (more than 2/3), however, proceeds via cyanoethylation of glutathione, to N-acetyl-S-(2-cyanoethyl)cysteine (AN-mercapturic acid) as a final product.

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