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. 1980;27(4):232-7.
doi: 10.1159/000131491.

Chromosomal mapping of human creatine kinase (brain type) using human-rodent somatic cell hybrids

C J Chern, P Tan, H Park

Chromosomal mapping of human creatine kinase (brain type) using human-rodent somatic cell hybrids

C J Chern et al. Cytogenet Cell Genet. 1980.

Abstract

Concordant segregation of human brain-type creatine kinase, CK(BB), expression with nucleoside phosphorylase (NP) expression and the presence of chromosome 14 was observed in 53 independently derived cell hybrids between CK(BB)-positive human cells and CK(BB)-negative rodent cells. Further analysis of 26 subclones of two CK(BB)-positive human-mouse cell hybrids confirmed the positive correlation of CK(BB) expression with NP expression. The results suggest that the gene coding for human CK(BB) can be assigned to chromosome 14.

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