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. 1980 Nov;77(11):6368-70.
doi: 10.1073/pnas.77.11.6368.

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis

L M Hjelmeland

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis

L M Hjelmeland. Proc Natl Acad Sci U S A. 1980 Nov.

Abstract

The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.

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References

    1. Science. 1972 Feb 18;175(4023):720-31 - PubMed
    1. Biochim Biophys Acta. 1975 Mar 25;415(1):29-79 - PubMed
    1. Biochim Biophys Acta. 1976 Jun 4;436(1):38-44 - PubMed
    1. Biochim Biophys Acta. 1976 Oct 26;457(2):133-70 - PubMed
    1. Biochim Biophys Acta. 1977 Feb 14;465(1):68-76 - PubMed

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