doi: 10.1073/pnas.77.11.6889.
Studies with [35S]methionine indicate that the 22,000-dalton [Met]enkephalin-containing protein in chromaffin cells is a precursor of [Met]enkephalin
- PMID: 6935690
- PMCID: PMC350396
- DOI: 10.1073/pnas.77.11.6889
Item in Clipboard
Studies with [35S]methionine indicate that the 22,000-dalton [Met]enkephalin-containing protein in chromaffin cells is a precursor of [Met]enkephalin
Proc Natl Acad Sci U S A.
1980 Nov.
Abstract
It has been shown that [35S]methionine is incorporated into the [Met]enkephalin sequences of a 22,000-dalton enkephalin-containing protein in the adrenal medulla. Pulse-chase experiments indicate that label is incorporated into the large polypeptide before it appears in free [Met]enkephalin and a smaller [Met]enkephalin-containing peptide. These findings provide direct evidence of a precursor-product relationship of these structurally related polypeptides.
Similar articles
-
Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin.Proc Natl Acad Sci U S A. 1981 Mar;78(3):1962-6. doi: 10.1073/pnas.78.3.1962. Proc Natl Acad Sci U S A. 1981. PMID: 6940201 Free PMC article.
-
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.Science. 1980 Jun 27;208(4451):1459-61. doi: 10.1126/science.7384787. Science. 1980. PMID: 7384787
-
Enkephalin biosynthetic pathway: proteins of 8000 and 14,000 daltons in bovine adrenal medulla.Proc Natl Acad Sci U S A. 1980 Aug;77(8):5018-20. doi: 10.1073/pnas.77.8.5018. Proc Natl Acad Sci U S A. 1980. PMID: 6933544 Free PMC article.
-
Biochemistry of the enkephalins and enkephalin-containing peptides.Arch Biochem Biophys. 1983 Mar;221(2):309-23. doi: 10.1016/0003-9861(83)90149-2. Arch Biochem Biophys. 1983. PMID: 6340606 Review.
-
Biosynthesis of the enkephalins and enkephalin-containing polypeptides.Annu Rev Pharmacol Toxicol. 1983;23:353-72. doi: 10.1146/annurev.pa.23.040183.002033. Annu Rev Pharmacol Toxicol. 1983. PMID: 6307125 Review.
Cited by
-
Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands.Proc Natl Acad Sci U S A. 1980 Dec;77(12):7473-5. doi: 10.1073/pnas.77.12.7473. Proc Natl Acad Sci U S A. 1980. PMID: 6938986 Free PMC article.
-
Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin.Proc Natl Acad Sci U S A. 1981 Mar;78(3):1962-6. doi: 10.1073/pnas.78.3.1962. Proc Natl Acad Sci U S A. 1981. PMID: 6940201 Free PMC article.
-
Detection and partial characterization of proenkephalin mRNA.Proc Natl Acad Sci U S A. 1981 Sep;78(9):5484-7. doi: 10.1073/pnas.78.9.5484. Proc Natl Acad Sci U S A. 1981. PMID: 6946486 Free PMC article.
-
Methionine-enkephalin-like immunoreactivity in the nervous ganglion and the ovary of a protochordate, Ciona intestinalis.Cell Tissue Res. 1984;236(1):165-70. doi: 10.1007/BF00216527. Cell Tissue Res. 1984. PMID: 6370451
-
Adrenal opioid proteins of 8600 and 12,600 daltons: intermediates in proenkephalin processing.Proc Natl Acad Sci U S A. 1982 Mar;79(6):2096-100. doi: 10.1073/pnas.79.6.2096. Proc Natl Acad Sci U S A. 1982. PMID: 6952256 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
