Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Dec;77(12):7024-8.
doi: 10.1073/pnas.77.12.7024.

Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence

B Wasylyk, R Derbyshire, A Guy, D Molko, A Roget, R Téoule, P Chambon

Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence

B Wasylyk et al. Proc Natl Acad Sci U S A. 1980 Dec.

Abstract

A single-point mutation, consisting of a T-to-G transversion, was made in the third nucleotide of the conalbumin gene T-A-T-A-A-A-A homology sequence (the T-A-T-A or Goldberg-Hogness box). In an in vitro system, specific transcription of the mutant DNA was drastically decreased compared to the normal gene. This down-mutation is consistent with the idea that the T-A-T-A box is an important element for specific initiation of transcription.

PubMed Disclaimer

References

    1. Annu Rev Genet. 1979;13:319-53 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):784-8 - PubMed
    1. Gene. 1979 Dec;8(1):81-97 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1432-6 - PubMed
    1. Cell. 1980 Jun;20(2):269-81 - PubMed

Publication types

LinkOut - more resources