Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Dec;77(12):7204-8.
doi: 10.1073/pnas.77.12.7204.

Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG)

G J Quigley, A H Wang, G Ughetto, G van der Marel, J H van Boom, A Rich

Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG)

G J Quigley et al. Proc Natl Acad Sci U S A. 1980 Dec.

Abstract

The structure of the crystalline daunomycin-d(CpGpTpApCpG) complex has been solved by x-ray diffraction analysis. The DNA forms a six-base-pair right-handed double helix with two daunomycin molecules intercalated in the d(CpG) sequences. The daunomycin aglycone chromophore is oriented at right angles to the long dimension of the DNA base pairs and the cyclohexene ring rests in the minor groove. Substituents on this ring have hydrogen bonding interactions to the base pairs above and below the intercalation site. These appear to be specific for anthracycline antibiotics. The amino sugar lies in the minor groove of the double helix without bonding to the DNA. The DNA double helix is distorted in a novel manner in accommodating the drug.

PubMed Disclaimer

References

    1. J Mol Biol. 1970 Dec 14;54(2):247-79 - PubMed
    1. Nat New Biol. 1972 Jan 5;235(53):17-9 - PubMed
    1. J Mol Biol. 1974 Nov 15;89(4):783-801 - PubMed
    1. Biochemistry. 1976 May 18;15(10):2062-70 - PubMed
    1. J Mol Biol. 1977 Aug 15;114(3):301-15 - PubMed

Publication types

LinkOut - more resources