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. 1981 Jan;78(1):13-5.
doi: 10.1073/pnas.78.1.13.

Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle

A R Battersby, M J Bushell, C Jones, N G Lewis, A Pfenninger

Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle

A R Battersby et al. Proc Natl Acad Sci U S A. 1981 Jan.

Abstract

Incorporation experiments with labeled sirohydrochlorin and trimethylisobacteriochlorin demonstrate that ring contraction in vivo to the corrin macrocycle of vitamin B12 liberates acetic acid. The C-20 atom of the precursors becomes the acetate carboxyl carbon.

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References

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