Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Feb;78(2):1162-6.
doi: 10.1073/pnas.78.2.1162.

Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations

T L Low, S K Hu, A L Goldstein

Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations

T L Low et al. Proc Natl Acad Sci U S A. 1981 Feb.

Abstract

The amino acid sequence of thymosin beta 4, a polypeptide isolated from calf thymus, was determined. Thymosin beta 4 is composed of 43 amino acid residues and has a molecular weight of 4982 and an isoelectric point of 5.1. The NH2 terminus of the peptide is blocked by an acetyl group. This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro. Thus, it appears that thymosin beta 4 acts on lymphoid stem cells and may control the early stages of the maturation process of thymus-dependent lymphocytes. This peptide is one of several present in thymosin fraction 5 that participates in the regulation, differentiation, and function of thymus-dependent thymocytes.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 1976;277(00):609-20 - PubMed
    1. Ann N Y Acad Sci. 1979;332:81-94 - PubMed
    1. Nature. 1966 Aug 6;211(5049):591-3 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Sep;56(3):1010-7 - PubMed
    1. Anal Biochem. 1969 May;29(2):186-92 - PubMed

Publication types

LinkOut - more resources