The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA)

Abstract

The authors have pointed out a monosodium-urate (MSU) skin test in vivo, showing a practical usefulness in short-time evaluation of effects of non-steroidal antiphlogistic drugs (NSAID) in man; the isotopic curves, in the area of the skin test, reproduce those obtained in endogenous articular phlogosis. THe authors have studied, at the same time, the actions of NSAID on other skin tests (SK-SD; PHA) which reproduce, in earlier phases of cutaneous reaction, some aspects (erythema, thermographic values, isotopic curves) of 'immediators' phlogosis. The results show that the MSU skin test is more useful in studying the effects of NSAID for the feature of other skin test reactions are affected by many factors.