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. 1981 May;33(3):381-95.

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs

S E Hodge

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs

S E Hodge. Am J Hum Genet. 1981 May.

Abstract

A two-locus disease model is presented in which a marker locus interacts epistatically with another unlinked trait to cause the disease. Such a model can lead to disease-marker associations and distortions in the sharing of marker types among affected family members. These effects are quantified. In the case of HLA-disease associations, this model is presented as an alternative to the "hitchhiking" theory of tight linkage leading to linkage disequilibrium.

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