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. 1981 May;78(5):3044-8.
doi: 10.1073/pnas.78.5.3044.

Angiotensin alters 45Ca2+ fluxes in bovine adrenal glomerulosa cells

M E Elliott, T L Goodfriend

Angiotensin alters 45Ca2+ fluxes in bovine adrenal glomerulosa cells

M E Elliott et al. Proc Natl Acad Sci U S A. 1981 May.

Abstract

Angiotensin II stimulated 45Ca2+ release from bovine adrenal glomerulosa cells. It also decreased the influx of 45Ca2+ into glomerulosa cells. The effects were observed within 2 min of hormone addition and were blocked by Saralasin a competitive inhibitor of angiotensin. Des-Phe8-angiotensin II, a biologically inert analog, was inactive in this system. Angiotensin II also inhibited the influx of 133Ba2+ and 54Mn2+, whereas 51Cr6+ and 57Co2+ were unaffected. Alterations in 45Ca2+ fluxes were seen with concentrations of angiotensin that stimulate aldosterone biosynthesis in bovine glomerulosa cell preparations. These results suggest that calcium plays a key role in angiotensin-stimulated aldosteronogenesis.

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