Double blind controlled trial of deanol in tardive dyskinesia

Abstract

Thirty three chronic psychiatric hospital subjects with oral tardive dyskinesia were divided into three groups. The subjects were matched for severity of symptoms then randomly assigned to treatment with a placebo, 1 g deanol or 2 g deanol per day. Statistical analysis showed that after 30 days treatment, there was a significant reduction in the mean rating of the movements of the group of 11 subjects on 2 g deanol per day. Six of these subjects showed substantial reduction in movement. Further studies using this dosage of deanol are unwarranted.