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. 1981 Mar;70(3):272-6.
doi: 10.1002/jps.2600700312.

Stability of N-formimidoylthienamycin in aqueous solution

G B Smith, E F Schoenewaldt

Stability of N-formimidoylthienamycin in aqueous solution

G B Smith et al. J Pharm Sci. 1981 Mar.

Abstract

The stability of N-formimidoylthienamycin in aqueous solution at 25 and 40 degrees was determined. In pH 5-8 nonnucleophilic inert buffers, pseudo-first-order ring opening was observed with dilute solutions (1 or 2 mg/ml initially). At higher initial concentrations, a second-order reaction also was evident. The rate data were compared with literature data for various cephalosporins and penicillins.

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