Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul;21(1):29-39.
doi: 10.1111/j.1600-0609.1978.tb02492.x.

Iron kinetics and erythropoiesis in Fanconi's anaemia

G Barosi, M Cazzola, A Marchi, S Morandi, V Perani, M Stefanelli, S Perugini

Iron kinetics and erythropoiesis in Fanconi's anaemia

G Barosi et al. Scand J Haematol. 1978 Jul.

Abstract

Ferrokinetic studies were carried out in 4 patients with Fanconi's anaemia (FA). Experimental data were analysed by means of a mathematical model of iron kinetics in order to obtain a quantitative assessment of effective and ineffective erythropoietic activity, mean red cell lifespan, and non-erythroid iron turnover. The major pathogenetic mechanism of the anaemia appeared to be relative marrow failure, i.e. a reduction in the proliferative capacity of the erythroid marrow. The role of ineffective erythropoiesis was of minor importance. On the basis of the results obtained both the pathogenesis and the natural course of the disease are discussed.

PubMed Disclaimer