Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Mar;43(3):478-85.

Increased frequency of B8/DR3 in scleroderma and association of the haplotype with impaired cellular immune response

C G Kallenberg, J M Van der Voort-Beelen, J D'Amaro, T H The

Increased frequency of B8/DR3 in scleroderma and association of the haplotype with impaired cellular immune response

C G Kallenberg et al. Clin Exp Immunol. 1981 Mar.

Abstract

Twenty-eight patients with scleroderma were typed for 40 HLA antigens. A highly significant increase in the frequency of HLA-B8 and HLA-DR3 was observed, which was not related to the severity of the disease. In vitro lymphocyte stimulation tests were performed in 26 patients. In addition, humoral and in vitro cellular immune responses to a primary test antigen were measured in 12 of them. Although the group of scleroderma patients as a whole had an impaired cellular response, only the B8/DR3+ patients had a strongly depressed response, whereas the immune response of the others was normal. These findings suggest an association of the haplotype B8/DR3 with impaired cellular immunity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ann Hum Genet. 1955 Jun;19(4):251-3 - PubMed
    1. Tissue Antigens. 1973;3(6):470-6 - PubMed
    1. Arthritis Rheum. 1975 May-Jun;18(3):219-28 - PubMed
    1. Lancet. 1975 Feb 15;1(7903):363-6 - PubMed
    1. Nature. 1978 Mar 23;272(5651):359-61 - PubMed

LinkOut - more resources