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Comparative Study
. 1981 Oct;12(4):507-10.
doi: 10.1111/j.1365-2125.1981.tb01258.x.

The pharmacokinetics of subcutaneous cytosine arabinoside in patients with acute myelogenous leukaemia

M L Slevin, E M Piall, G W Aherne, A Johnston, M C Sweatman, T A Lister
Comparative Study

The pharmacokinetics of subcutaneous cytosine arabinoside in patients with acute myelogenous leukaemia

M L Slevin et al. Br J Clin Pharmacol. 1981 Oct.

Abstract

1 The pharmacokinetics of subcutaneous cytosine arabinoside were compared with bolus intravenous injection and intravenous infusion in five patients with acute myelogenous leukaemia. 2 Subcutaneous cytosine arabinoside was rapidly absorbed and then declined biexponentially with initial and terminal half-lives similar to intravenous bolus injection. 3 Cytosine arabinoside levels declined rapidly after intravenous bolus and subcutaneous bolus injection, and fell below steady state infusion levels after a mean time of 40 min (intravenous bolus) and 100 min (subcutaneous injection).

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