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Case Reports
. 1981 Dec 1;59(23):1319-20.
doi: 10.1007/BF01711182.

Increased ammonia production during forearm ischemic work test in McArdle's disease

K W Rumpf, H Wagner, H Kaiser, H M Meinck, H H Goebel, F Scheler
Case Reports

Increased ammonia production during forearm ischemic work test in McArdle's disease

K W Rumpf et al. Klin Wochenschr. .

Abstract

A patient with typical features of late onset McArdle's disease is described. During forearm ischemic work test the patient exhibited an exaggerated increase in ammonia release, largely exceeding normal values. It is suggested, that this is due to an activation of the myokinase/myoadenylate deaminase pathway. Besides lack of lactate release increased ammonia release during ischemia may be a typical feature of McArdle's disease.

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