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. 1981 Nov;78(11):7111-4.
doi: 10.1073/pnas.78.11.7111.

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis

L Steinman, J T Rosenbaum, S Sriram, H O McDevitt

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis

L Steinman et al. Proc Natl Acad Sci U S A. 1981 Nov.

Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

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