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. 1981 Jul;18(1):35-9.
doi: 10.1111/j.1399-0039.1981.tb01358.x.

Association of HLA antigens with coeliac disease among Iraqi children

F H Dawood, A A Jabbar, A F Al-Mudaris, M H Al-Hasani

Association of HLA antigens with coeliac disease among Iraqi children

F H Dawood et al. Tissue Antigens. 1981 Jul.

Abstract

Forty children with coeliac disease were subjected to HLA-A and B antigens typing using the two-way lymphocytotoxicity technique. An increase in the frequency of HLA-B8 and B12 was found in patients as compared to the control group. Family studies conducted in 4 selected families have indicated that four out of five siblings who inherited the HLA-B8 antigen from their parents have contracted coeliac disease. In one of the families both siblings had HLA-B8 but only one of them contracted coeliac disease. It is suggested that the association of coeliac disease with HLA-antigen could be multifactorial, i.e. the disease could be attributed to the presence of more than one antigen.

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