Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jan;79(2):606-7.
doi: 10.1073/pnas.79.2.606.

Allelic exclusion of immunoglobulin expression is not caused by somatic segregation

M R Wabl, M Tenkhoff

Allelic exclusion of immunoglobulin expression is not caused by somatic segregation

M R Wabl et al. Proc Natl Acad Sci U S A. 1982 Jan.

Abstract

We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Exp Med. 1965 Nov 1;122(5):853-76 - PubMed
    1. J Exp Med. 1966 Mar 1;123(3):547-58 - PubMed
    1. Chromosoma. 1972;39(3):265-88 - PubMed
    1. Chromosoma. 1973;41(2):145-58 - PubMed
    1. Transplant Rev. 1973;14:76-130 - PubMed

LinkOut - more resources