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. 1982 Apr;12(4):354-7.
doi: 10.1002/eji.1830120418.

Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells

S Carrel, N De Tribolet, N Gross

Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells

S Carrel et al. Eur J Immunol. 1982 Apr.

Abstract

The expression on several established human glioma cell lines of two well-defined differentiation antigens, HLA-DR and the common acute lymphoblastic leukemia antigen (CALLA) has been demonstrated. Rabbit anti-CALLA antiserum and monoclonal anti-Ia antibodies specifically lysed glioma cells in the presence of complement. Absorption of anti-CALLA antiserum and anti-Ia antibodies by glioma cells abolished their cytotoxicity against blasts isolated from a common acute lymphoblastic leukemia. Immunoprecipitation of solubilized glioma cells by monoclonal anti-Ia antibodies revealed two polypeptide chains of 28 and 33 kDa, whereas the anti-CALLA antiserum precipitated a single polypeptide chain of 100 kDa.

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