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. 1982 Jun;79(11):3523-6.
doi: 10.1073/pnas.79.11.3523.

NMR chemical shift imaging in three dimensions

T R Brown, B M Kincaid, K Ugurbil

NMR chemical shift imaging in three dimensions

T R Brown et al. Proc Natl Acad Sci U S A. 1982 Jun.

Abstract

A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.

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References

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