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. 1982 Jul;79(13):3968-72.
doi: 10.1073/pnas.79.13.3968.

Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA

A H Wang, S Fujii, J H van Boom, A Rich

Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA

A H Wang et al. Proc Natl Acad Sci U S A. 1982 Jul.

Abstract

The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.

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